Article
The role of sequence variations within the genes encoding collagen II, IX and XI in non-syndromic, early-onset osteoarthritis.
Osteoarthritis and cartilage - 1 Jun 2005
Jakkula E, Melkoniemi M, Kiviranta I, Lohiniva J, Räinä S S, Perälä M, Warman M L, Ahonen K, Kröger H, Göring H H H, Ala-Kokko L
Abstract excerpt
OBJECTIVE: We sought to determine whether sequence variations in cartilage collagen genes are associated with primary, early-onset osteoarthritis (OA). METHODS: The cartilage collagen genes, COL2A1, COL9A1, COL9A2, COL9A3, COL11A1 and COL11A2, were screened for sequence variations in 72 Finnish probands and one US family with primary early-onset hip and/or knee OA. In addition, allelic association studies were...
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