Article
Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis.
Rheumatology (Oxford, England) - 1 Mar 2000
Mustafa Z, Chapman K, Irven C, Carr A J, Clipsham K, Chitnavis J, Sinsheimer J S, Bloomfield V A, McCartney M, Cox O, Sykes B, Loughlin J
Abstract excerpt
OBJECTIVE: To examine 11 candidate genes as susceptibility loci for osteoarthritis (OA). METHODS: A total of 481 families have been ascertained in which at least two siblings have had joint replacement surgery of the hip, or knee, or hip and knee for idiopathic OA. Each candidate gene was targeted using one or more intragenic or closely linked microsatellite marker. The linkage data were analysed unstratified and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
