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Article

Specific VDJ gene combinations contribute to the specificity of memory antibodies to the phosphorylcholine hapten.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1992

Lötscher M, Amstutz H, Heusser C H, Blaser K

Abstract excerpt

Based on their fine specificity, two groups of antibodies against the phosphorylcholine (PC) hapten have been described. Group I antibodies react predominantly with the PC moiety of the hapten and group II are directed against the entire hapten including the azophenyl spacer to the protein carrier. We have analyzed the VH gene segment utilization of hybridomas from the memory response to PC by Southern blot...

Topics

Amino Acid Sequence
Animals
Antibody Specificity
Base Sequence
Blotting, Southern
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Haptens
Hybridomas
Immunologic Memory
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Phosphorylcholine

Structure-Activity Relationship

Source

Identifiers

PMID: 1588049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1588049-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Specific VDJ gene combinations contribute to the specificity of memory antibodies to the phosphorylcholine hapten.PMID 1588049Read ↗

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