Article
Replacements in the exposed loop of the T15 antibody VH CDR2 affect carrier recognition of PC-containing pathogens.
Molecular immunology - 1 Feb 1999
Brown M, Wiens G D, O'Hare T, Stenzel-Poore M P, Rittenberg M B
Abstract excerpt
A panel of mutant antibodies of the phosphocholine (PC)-binding antibody, T15, was tested for binding to PC-protein, Streptococcus pneumoniae, Trichinella spiralis and Ascaris suum. Relative to wildtype T15, all the mutant antibodies showed differential recognition of the panel of PC-associated antigens. These mutant antibodies contain amino acid replacements in the CDR2 region of the heavy chain variable region,...
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