Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3.

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Article

Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1991

Chen C, Stenzel-Poore M P, Rittenberg M B

Abstract excerpt

We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%. These sets were found among 49 neonatal and adult natural mAb that were compared with 35 Ag-induc...

Topics

Amino Acid Sequence
Animals
Antibodies
Base Sequence
Genes, Immunoglobulin
Hybridomas
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Phenotype

Source

Open in PubMed

Identifiers

PMID: 1918968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1918968-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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