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Article

Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigen.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1992

Brown M, Stenzel-Poore M, Stevens S, Kondoleon S K, Ng J, Bächinger H P, Rittenberg M B

Abstract excerpt

Anti-phosphocholine (PC)-keyhole limpet hemacyanin hybridomas representative of a memory response that express the lambda 1 L chain isotype have a high reactivity to PC-protein. A common feature of these hybridomas possessing high affinity for PC-protein is the occurrence of somatic mutations resulting in replacement changes in three CDR2 positions of the lambda 1 L chain. The influence of each of these three...

Topics

Animals
Antibody Affinity
Base Sequence
Genes, Immunoglobulin
Hemocyanins
Hybridomas
Immunoglobulin Variable Region
Immunoglobulin lambda-Chains
Immunologic Memory
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Phosphorylcholine

Source

Identifiers

PMID: 1729358

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1729358-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigen.PMID 1729358Read ↗

Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3.Semantic proximity Read ↗

Specific VDJ gene combinations contribute to the specificity of memory antibodies to the phosphorylcholine hapten.Semantic proximity Read ↗

Repertoire shift in the humoral response to phosphocholine-keyhole limpet hemocyanin: VH somatic mutation in germinal center B cells impairs T15 Ig function.Semantic proximity Read ↗

Mutation of a single conserved residue in VH complementarity-determining region 2 results in a severe Ig secretion defect.Semantic proximity Read ↗

Initiation of the phosphocholine-specific response to Proteus morganii. B cell transfectants expressing unmutated VH/VL can respond to stimulation by P. morganii antigen.Semantic proximity Read ↗

Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold.Semantic proximity Read ↗

Mutation and selection during the secondary response to 2-phenyloxazolone.Semantic proximity Read ↗

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.Semantic proximity Read ↗

Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotype.Semantic proximity Read ↗

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