Article
The fine-scale structure of recombination rate variation in the human genome.
Science (New York, N.Y.) - 23 Apr 2004
McVean Gilean A T, Myers Simon R, Hunt Sarah, Deloukas Panos, Bentley David R, Donnelly Peter
Abstract excerpt
The nature and scale of recombination rate variation are largely unknown for most species. In humans, pedigree analysis has documented variation at the chromosomal level, and sperm studies have identified specific hotspots in which crossing-over events cluster. To address whether this picture is representative of the genome as a whole, we have developed and validated a method for estimating recombination rates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.