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Article

Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2011

Lu Jinghua, Marjon Kristopher D, Marnell Lorraine L, Wang Ruipeng, Mold Carolyn, Du Clos Terry W, Sun Peter

Abstract excerpt

C-reactive protein (CRP) is an important biomarker for inflammatory diseases. However, its role in inflammation beyond complement-mediated pathogen clearance remains poorly defined. We identified the major IgA receptor, FcαRI, as a ligand for pentraxins. CRP recognized FcαRI both in solution and on cells, and the pentraxin binding site on the receptor appears distinct from that recognized by IgA. Further...

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Share to C-Reactive Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21383176
DOI: 10.1073/pnas.1018369108
PMCID: PMC3064353

Genes

CRP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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