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Topology and Structure of the C1q-Binding Site on C-Reactive Protein

1 Mar 2001

Abstract excerpt

The host defense functions of human C-reactive protein (CRP) depend to a great extent on its ability to activate the classical complement pathway. The aim of this study was to define the topology and structure of the CRP site that binds C1q, the recognition protein of the classical pathway. We have previously reported that residue Asp(112) of CRP plays a major role in the formation of the C1q-binding site, while...

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PMID: 11238646
DOI: 10.4049/jimmunol.166.6.3998

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