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Article

Structure-Function Analysis of the Active Sites of Complement Receptor Type 1

1 Apr 1998

Abstract excerpt

Two functionally distinct but homologous sites in complement receptor type 1 (CR1) (CD35) were further characterized by homologous substitution mutagenesis of two CR1 derivatives, each containing one site. In both sites, reducing negative and/or increasing positive charge augmented interaction with iC3/C3b and C4b, supporting a role of ionic forces in the binding reaction. In one case, substitution of Asp at the...

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PMID: 9535836
DOI: 10.1074/jbc.273.15.8623

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