Article
The genotoxic effects of arachidonic acid in V79 cells are mediated by peroxidation products.
Toxicology and applied pharmacology - 1 Aug 1993
Zhang J R, Sevanian A
Abstract excerpt
Chinese hamster lung fibroblasts (V79 cells) were exposed to 2, 20, 160, and 200 microM arachidonic acid (AA). At 20 microM, a stimulatory effect on cell growth was observed, while at 200 microM, an inhibitory effect was found. AA at 160 and 200 microM induced a 10- to 12-fold increase of 6-thiog...
Topics
- Animals
- Arachidonic Acid
- Cell Division
- Cell Survival
- Cells, Cultured
- Chromatography, High Pressure Liquid
- Cricetinae
- DNA Damage
- Fibroblasts
- Lipid Peroxidation
- Lung
- Masoprocol
- Mutation
- Thioguanine
- Vitamin E