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Article

The genotoxic effects of arachidonic acid in V79 cells are mediated by peroxidation products.

Toxicology and applied pharmacology - 1 Aug 1993

Zhang J R, Sevanian A

Abstract excerpt

Chinese hamster lung fibroblasts (V79 cells) were exposed to 2, 20, 160, and 200 microM arachidonic acid (AA). At 20 microM, a stimulatory effect on cell growth was observed, while at 200 microM, an inhibitory effect was found. AA at 160 and 200 microM induced a 10- to 12-fold increase of 6-thioguanine-resistant mutants in V79 cells, whereas increased alkaline labile sites on DNA were consistently produced only...

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Identifiers

PMID: 8346536
DOI: 10.1006/taap.1993.1145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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