Article
Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.
The American journal of pathology - 1 Dec 2002
Konger Raymond L, Scott Glynis A, Landt Yvonne, Ladenson Jack H, Pentland Alice P
Abstract excerpt
Prostaglandin E(2) (PGE(2)) receptor subtype EP(2), which is coupled to cAMP metabolism, is known to mediate proliferation of primary human keratinocytes in vitro. The effect of gain or loss of EP(2) receptors in immortalized human keratinocytes (HaCat cells) was examined. HaCat keratinocytes were transfected with sense or anti-sense constructs of the EP(2) receptor. Loss or gain of EP(2) expression was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.