Article
EGF and TGF alpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: possible role of the arachidonic acid pathway.
Journal of cellular biochemistry - 1 Mar 1995
Spitzer E, Zschiesche W, Binas B, Grosse R, Erdmann B
Abstract excerpt
Epidermal growth factor (EGF) has been suggested to be involved in mammary gland development by mitogenic stimulation of the ductal and alveolar epithelium in virgin mice. The present studies demonstrate that also in late-pregnant mice EGF leads to proliferation of the ductal, ductular, and alveo...
Topics
- Animals
- Arachidonic Acid
- Cell Differentiation
- Cytarabine
- Epidermal Growth Factor
- Epithelial Cells
- Female
- Mammary Glands, Animal
- Mice
- Mice, Inbred BALB C
- Milk
- Mitogens
- Organ Culture Techniques
- Phenotype
- Pregnancy
- Pregnancy, Animal
- Protein Kinase C
- Transforming Growth Factor alpha