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Article

Extrapolations are the Achilles heel of risk assessment.

Mutation research - 1 May 2005

Preston R J

Abstract excerpt

This Reflections article considers the problems associated with the various extrapolations that are required for the estimation of human cancer risks from exposure to environmental carcinogens at low doses. These include extrapolation between species (particularly rodent to human), from responses at high doses to those at low doses, and among different stages of life. Reductions in uncertainty in risk estimates...

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Identifiers

PMID: 15878140
DOI: 10.1016/j.mrrev.2005.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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