Article
Use of mechanistic models to estimate low-dose cancer risks.
Risk analysis : an official publication of the Society for Risk Analysis - 1 Dec 1994
Crump K S
Abstract excerpt
The utility of mechanistic models of cancer for predicting cancer risks at low doses is examined. Based upon a general approximation to the dose-response that is valid at low doses, it is shown that at low doses the dose-response predicted by a mechanistic model is a linear combination of the dose-responses for each of the physiological parameters in the model that are affected by exposure. This demonstrates...
Topics
- Carcinogens
- Dose-Response Relationship, Drug
- Humans
- Linear Models
- Models, Biological
- Mutation
- Neoplasms
- Radon
- Risk Assessment
- Stochastic Processes