Article
Methods for predicting carcinogenic hazards: new opportunities coming from recent developments in molecular oncology and SAR studies.
Mutation research - 13 Jun 1997
Taningher M, Malacarne D, Mancuso T, Peluso M, Pescarolo M P, Parodi S
Abstract excerpt
Without epidemiological evidence, and prior to either short-term tests of genotoxicity or long-term tests of carcinogenicity in rodents, an initial level of information about the carcinogenic hazard of a chemical that perhaps has been designed on paper, but never synthesized, can be provided by structure-activity relationship (SAR) studies. Herein, we have reviewed the interesting strategies developed by human...
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