Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dose-response relationships in chemical carcinogenesis: from DNA adducts to tumor incidence.

Advances in experimental medicine and biology - 1 Jan 1991

Lutz W K

Abstract excerpt

Mechanistic possibilities responsible for nonlinear shapes of the dose-response relationship in chemical carcinogenesis are discussed. (i) Induction and saturation of enzymatic activation and detoxification processes and of DNA repair affect the relationship between dose and steady-state DNA adduct level; (ii) The fixation of DNA adducts in the form of mutations is accelerated by stimulation of the cell division,...

Topics

Animals
Carcinogens
DNA
Dose-Response Relationship, Drug
Humans
Mutation
Neoplasms
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2068982
DOI: 10.1007/978-1-4684-5877-0_16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2068982-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dose-response relationships in chemical carcinogenesis: from DNA adducts to tumor incidence.PMID 2068982Read ↗

Dose-response relationships in chemical carcinogenesis: superposition of different mechanisms of action, resulting in linear-nonlinear curves, practical thresholds, J-shapes.Semantic proximity Read ↗

Dose-response relationships in chemical carcinogenesis reflect differences in individual susceptibility. Consequences for cancer risk assessment, extrapolation, and prevention.Semantic proximity Read ↗

Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence.Semantic proximity Read ↗

Susceptibility differences in chemical carcinogenesis linearize the dose-response relationship: threshold doses can be defined only for individuals.Semantic proximity Read ↗

Cancer risk assessment at the crossroads: the need to turn to a biological approach.Semantic proximity Read ↗

Perspectives in low dose risk estimation.Semantic proximity Read ↗

The LNT model is the best we can do--today.Semantic proximity Read ↗

Genotoxic thresholds, DNA repair, and susceptibility in human populations.Semantic proximity Read ↗

Influence of DNA repair on nonlinear dose-responses for mutation.Semantic proximity Read ↗

Biomarkers in toxicology and risk assessment: informing critical dose-response relationships.Semantic proximity Read ↗

Hormesis: changing view of the dose-response, a personal account of the history and current status.Semantic proximity Read ↗

Risk assessment of non-genotoxic carcinogens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.