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Article

Dose-response relationships in chemical carcinogenesis: from DNA adducts to tumor incidence.

Advances in experimental medicine and biology - 1 Jan 1991

Lutz W K

Abstract excerpt

Mechanistic possibilities responsible for nonlinear shapes of the dose-response relationship in chemical carcinogenesis are discussed. (i) Induction and saturation of enzymatic activation and detoxification processes and of DNA repair affect the relationship between dose and steady-state DNA adduct level; (ii) The fixation of DNA adducts in the form of mutations is accelerated by stimulation of the cell division,...

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PMID: 2068982
DOI: 10.1007/978-1-4684-5877-0_16

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