Differences in individual susceptibility to toxic effects of chemicals determine the dose-response relationship and consequences of setting exposure standards.

Abstract excerpt

The dose-response curve obtained in toxicity testing is a mirror image of the susceptibility distribution in the treated population, i.e. it follows increasing tolerance of the individuals to the adverse effects of the chemical under investigation. Defining a dose as a maximum tolerated exposure level, therefore, splits the 'public' into two groups, those who are protected and those who are not, and the position...

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