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Article

Inactivation of the Candidate Tumor Suppressor <i>Par-4</i> in Endometrial Cancer

1 Mar 2007

Abstract excerpt

Recently, it has been shown that mice deficient in the proapoptotic protein prostate apoptosis response 4 (Par-4) are specifically prone to develop endometrial carcinomas. Based on this, we have examined here the possible role of Par-4 as a tumor suppressor gene in human endometrial cancer. Using cDNA arrays, quantitative reverse transcription-PCR, and immunohistochemistry, we detected Par-4 down-regulation in...

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PMID: 17332319
DOI: 10.1158/0008-5472.can-06-2687

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