Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.

Cell death and differentiation - 1 Oct 2014

Chen X, Sahasrabuddhe A A, Szankasi P, Chung F, Basrur V, Rangnekar V M, Pagano M, Lim M S, Elenitoba-Johnson K S J

Abstract excerpt

Prostate apoptosis response protein 4 (Par-4) also known as PRKC apoptosis WT1 regulator is a tumor suppressor that selectively induces apoptosis in cancer cells. However, its post-translational regulation by ubiquitin-mediated proteolysis and the cellular machinery that is responsible for its proteasomal degradation are unknown. Using immunopurification and an unbiased mass spectrometry-based approach, we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to F-Box Proteins

Share to Proteasome Endopeptidase Complex

Share to RNA, Small Interfering

Share to Staurosporine

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 24992930
DOI: 10.1038/cdd.2014.92
PMCID: PMC4158693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.PMID 24992930Read ↗

Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymoreSemantic proximity Read ↗

Apoptosis and tumor resistance conferred by Par-4Semantic proximity Read ↗

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells.Semantic proximity Read ↗

Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.Semantic proximity Read ↗

GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and SignalingSemantic proximity Read ↗

The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.Semantic proximity Read ↗

Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

ZBTB7A interferes with the RPL5‐P53 feedback loop and reduces endoplasmic reticulum stress‐induced apoptosis of pancreatic cancer cellsSemantic proximity Read ↗

New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies.Semantic proximity Read ↗

Cancer resistance in transgenic mice expressing the SAC module of Par-4.Semantic proximity Read ↗

Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR-targeted therapy response in colorectal cancer.Semantic proximity Read ↗

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.