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Article

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1

19 Jun 2019

Abstract excerpt

Most deaths from breast cancer result from tumour recurrence, which is typically an incurable disease. Down-regulation of the pro-apoptotic tumour suppressor protein prostate apoptosis response-4 (PAR-4) is required for breast cancer recurrence and resistance to chemotherapy. Recent advances in the analysis of apoptotic signalling networks have uncovered an important role for activation of caspase-8 following DNA...

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PMID: 31217499
DOI: 10.1038/s41598-019-45209-9

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