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The Tumor Suppressor Par-4 Regulates Adipogenesis by Transcriptional Repression of PPARγ

5 Sept 2024

Abstract excerpt

Prostate apoptosis response-4 (Par-4, also known as PAWR) is a ubiquitously expressed tumor suppressor protein that induces apoptosis selectively in cancer cells, while leaving normal cells unaffected. Our previous studies indicated that genetic loss of Par-4 promoted hepatic steatosis, adiposity, and insulin-resistance in chow-fed mice. Moreover, low plasma levels of Par-4 are associated with obesity in human...

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PMID: 39273065
DOI: 10.3390/cells13171495

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