Pharmacogenetics of Opioid Response

Abstract excerpt

For opioids requiring CYP2D6 O-demethylation to active metabolites, poor metabolizers have reduced metabolite formation and minimal pain reduction. Clinically, this has only reliably been shown for tramadol. Ultra-rapid metabolizers have an increased risk of toxicity especially for codeine. ABCB1 genetics show no consistent findings. In Asian populations, the high OPRM1 118A>G frequency associates with higher...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pain Management and Opioid Use
• Share to Pharmacogenetics and Drug Metabolism