Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteers.

Abstract excerpt

Polymorphisms in the mu-opioid receptor gene (OPRM1) are primary candidate sources of clinical variability in opioid therapy. Apart from the 118A>G single nucleotide polymorphism, nothing is known about the role of OPRM1 mutations in opioid therapy. The influence of the OPRM1 mutations on opioid pharmacodynamics was assessed in pooled data from 31 healthy volunteers obtained in previous studies with available...

Topics

• Alleles
• Exons
• Female
• Gene Frequency
• Humans
• Male
• Mutation
• Narcotics
• Polymorphism, Genetic
• Receptors, Opioid, mu
• Reference Values