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Article

Dynamin Forms a Src Kinase–sensitive Complex with Cbl and Regulates Podosomes and Osteoclast Activity

5 May 2005

Abstract excerpt

Podosomes are highly dynamic actin-containing adhesion structures found in osteoclasts, macrophages, and Rous sarcoma virus (RSV)-transformed fibroblasts. After integrin engagement, Pyk2 recruits Src and the adaptor protein Cbl, forming a molecular signaling complex that is critical for cell migration, and deletion of any molecule in this complex disrupts podosome ring formation and/or decreases osteoclast...

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PMID: 15872089
DOI: 10.1091/mbc.e04-12-1117

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Dynamin Forms a Src Kinase–sensitive Complex with Cbl and Regulates Podosomes and Osteoclast ActivityPMID 15872089Read ↗

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Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formationSemantic proximity Read ↗

Src kinase activity is essential for osteoclast function.Semantic proximity Read ↗

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The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant.Semantic proximity Read ↗

Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.Semantic proximity Read ↗

A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells.Semantic proximity Read ↗

The osteoclast and its unique cytoskeletonSemantic proximity Read ↗

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