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Article

The osteoclast and its unique cytoskeleton

1 Dec 2011

Abstract excerpt

The osteoclast cytoskeleton is a unique structure that polarizes the cell's resorptive machinery to the bone-cell interface where it creates an isolated resorptive microenvironment consisting of an actin ring surrounding a ruffled border. This polarization process occurs under the aegis of the α(v) β(3) integrin in collaboration with the M-CSF receptor, c-Fms. When occupied, α(v) β(3) activates a canonical...

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PMID: 22172034
DOI: 10.1111/j.1749-6632.2011.06283.x

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