The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant.

Abstract excerpt

Several studies have shown that an EGF receptor C-terminal truncation at residue 973 (CT973) attenuates ligand-induced receptor endocytosis and is associated with cell transformation. Previously, we have shown that EGF stimulation of murine B82L fibroblasts expressing CT973 EGF receptors can promote the tyrosine phosphorylation of caveolin-1, which is a major component of caveolae membranes. Because dynamin plays...

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