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Article

Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.

Cell biochemistry and function - 1 Apr 2020

Kobayakawa Miki, Matsubara Takuma, Mizokami Akiko, Hiura Fumitaka, Takakura Nana, Kokabu Shoichiro, Matsuda Miho, Yasuda Hisataka, Nakamura Ichiro, Takei Yosuke, Honda Hiroaki, Hosokawa Ryuji, Jimi Eijiro

Abstract excerpt

Podosome formation in osteoclasts is an important initial step in osteoclastic bone resorption. Mice lacking c-Src (c-Src-/- ) exhibited osteopetrosis due to a lack of podosome formation in osteoclasts. We previously identified p130Cas (Crk-associated substrate [Cas]) as one of c-Src downstream molecule and osteoclast-specific p130Cas-deficient (p130CasΔOCL-/- ) mice also exhibited a similar phenotype to c-Src-/-...

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PMID: 31887784
DOI: 10.1002/cbf.3476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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