Article
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
The Journal of clinical investigation - 1 Aug 2007
Sever Sanja, Altintas Mehmet M, Nankoe Sharif R, Möller Clemens C, Ko David, Wei Changli, Henderson Joel, del Re Elizabetta C, Hsing Lianne, Erickson Ann, Cohen Clemens D, Kretzler Matthias, Kerjaschki Dontscho, Rudensky Alexander, Nikolic Boris, Reiser Jochen
Abstract excerpt
Kidney podocytes and their foot processes maintain the ultrafiltration barrier and prevent urinary protein loss (proteinuria). Here we show that the GTPase dynamin is essential for podocyte function. During proteinuric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin at an evolutionary conserved site, resulting in reorganization of the podocyte actin cytoskeleton and proteinuria....
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