Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortactin has an essential and specific role in osteoclast actin assembly.

Molecular biology of the cell - 1 Jul 2006

Tehrani Shandiz, Faccio Roberta, Chandrasekar Indra, Ross F Patrick, Cooper John A

Abstract excerpt

Osteoclasts are essential for bone dynamics and calcium homeostasis. The cells form a tight seal on the bone surface, onto which they secrete acid and proteases to resorb bone. The seal is associated with a ring of actin filaments. Cortactin, a c-Src substrate known to promote Arp2/3-mediated actin assembly in vitro, is expressed in osteoclasts and localizes to the sealing ring. To address the role of cortactin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Bone Resorption
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Dynamins

Share to Osteoclasts

Share to Point Mutation

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 16611741
DOI: 10.1091/mbc.e06-03-0187
PMCID: PMC1483026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortactin has an essential and specific role in osteoclast actin assembly.PMID 16611741Read ↗

The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro.Semantic proximity Read ↗

The transient appearance of zipper-like actin superstructures during the fusion of osteoclastsSemantic proximity Read ↗

Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclastsSemantic proximity Read ↗

Myosin X regulates sealing zone patterning in osteoclasts through linkage of podosomes and microtubules.Semantic proximity Read ↗

Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangementsSemantic proximity Read ↗

BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of OsteoclastsSemantic proximity Read ↗

The osteoclast and its unique cytoskeletonSemantic proximity Read ↗

CD44 and β3 Integrin Organize Two Functionally Distinct Actin-based Domains in OsteoclastsSemantic proximity Read ↗

p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.Semantic proximity Read ↗

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorptionSemantic proximity Read ↗

Molecular mechanisms of bone resorptionSemantic proximity Read ↗

Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.