Article
Generation of a tissue-specific transgenic model for K8 phosphomutants: A tool to investigate the role of K8 phosphorylation during skin carcinogenesis in vivo.
Cell biology international - 1 Aug 2021
Tiwari Richa, Ganguli Nirmalya, Alam Hunain, Sahu Indrajit, Vadivel Chella Krishna, Sinha Shruti, Patel Shweta, Jamghare Sayli Nitin, Bane Sanjay, Thorat Rahul, Majumdar Subeer S, Vaidya Milind M
Abstract excerpt
Keratin 8/18, the predominant keratin pair of simple epithelia, is known to be aberrantly expressed in several squamous cell carcinomas (SCCs), where its expression is often correlated with increased invasion, neoplastic progression, and poor prognosis. The majority of keratin 8/18 structural and regulatory functions are governed by posttranslational modifications, particularly phosphorylation. Apart from...
Topics
- Animals
- Carcinogenesis
- Electroporation
- HEK293 Cells
- Humans
- Keratin-8
- Male
- Mice
- Mice, Transgenic
- Mutation
- Phosphorylation
- Skin Neoplasms