Article
Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction.
Biological psychiatry - 15 May 2005
Caspi Avshalom, Moffitt Terrie E, Cannon Mary, McClay Joseph, Murray Robin, Harrington HonaLee, Taylor Alan, Arseneault Louise, Williams Ben, Braithwaite Antony, Poulton Richie, Craig Ian W
Abstract excerpt
BACKGROUND: Recent evidence documents that cannabis use by young people is a modest statistical risk factor for psychotic symptoms in adulthood, such as hallucinations and delusions, as well as clinically significant schizophrenia. The vast majority of cannabis users do not develop psychosis, however, prompting us to hypothesize that some people are genetically vulnerable to the deleterious effects of cannabis....
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