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Article

An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2006

Henquet Cécile, Rosa Araceli, Krabbendam Lydia, Papiol Sergi, Fananás Lourdes, Drukker Marjan, Ramaekers Johannes G, van Os Jim

Abstract excerpt

Observational studies have suggested that psychometric psychosis liability and a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderate the psychosis-inducing effect of cannabis. To replicate and extend this finding, a double-blind, placebo-controlled cross-o...

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Source

Identifiers

PMID: 16936704
DOI: 10.1038/sj.npp.1301197

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16936704-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.PMID 16936704Read ↗

Genetic moderation of the effects of cannabis: catechol-O-methyltransferase (COMT) affects the impact of Δ9-tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences.Semantic proximity Read ↗

The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.Semantic proximity Read ↗

Cannabis, COMT and psychotic experiences.Semantic proximity Read ↗

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction.Semantic proximity Read ↗

COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life.Semantic proximity Read ↗

COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions.Semantic proximity Read ↗

Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling study.Semantic proximity Read ↗

AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers.Semantic proximity Read ↗

COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.Semantic proximity Read ↗

COMT Val158Met moderation of stress-induced psychosis.Semantic proximity Read ↗

Genomic Variation Predicts Real-Time Δ <sup>9</sup> -tetrahydrocannabinol Response in HumansSemantic proximity Read ↗

Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.Semantic proximity Read ↗

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