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Article

Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications.

Psychiatry research - 30 Oct 2010

Pelayo-Terán José María, Pérez-Iglesias Rocío, Mata Ignacio, Carrasco-Marín Eugenio, Vázquez-Barquero José Luis, Crespo-Facorro Benedicto

Abstract excerpt

New models of interaction between genetic and environmental factors have been proposed to explain the pathogenesis of schizophrenia. The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis. The aim of the study was to explore the...

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Source

Identifiers

PMID: 20493536
DOI: 10.1016/j.psychres.2009.08.022

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications.PMID 20493536Read ↗

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