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Article

Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Brain and behavior - 1 Nov 2017

Lodhi Rohit J, Wang Yabing, Rossolatos David, MacIntyre Georgina, Bowker Alexandra, Crocker Candice, Ren Hongyan, Dimitrijevic Aleksandra, Bugbee Darren A, Loverock Alexandra, Majeau Brett, Sivapalan Sudhakar, Newton Virginia M, Tibbo Philip, Purdon Scot E, Aitchison Katherine J

Abstract excerpt

Objective: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods: One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical...

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Source

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Identifiers

PMID: 29201551
DOI: 10.1002/brb3.850
PMCID: PMC5698868

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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