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Article

The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia.

In vivo (Athens, Greece) - 1 Jan 2000

Ermis Aysegul, Erkiran Murat, Dasdemir Selcuk, Turkcan Ayse Solmaz, Ceylan Mehmet Emin, Bireller Elif Sinem, Cakmakoglu Bedia

Abstract excerpt

BACKGROUND/AIM: One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage. PATIENTS AND METHODS: The study group...

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Source

Identifiers

PMID: 25600541

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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