Article
The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism.
Schizophrenia research - 1 Oct 2013
Vinkers Christiaan H, Van Gastel Willemijn A, Schubart Christian D, Van Eijk Kristel R, Luykx Jurjen J, Van Winkel Ruud, Joëls Marian, Ophoff Roel A, Boks Marco P M, Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Kahn René S, Meijer Carin J, Myin-Germeys Inez, van Os Jim, Wiersma Durk
Abstract excerpt
BACKGROUND: Cannabis use and childhood maltreatment are independent risk factors for the development of psychotic symptoms. These factors have been found to interact in some but not all studies. One of the reasons may be that childhood maltreatment and cannabis primarily induce psychotic symptoms in genetically susceptible individuals. In this context, an extensively studied psychosis vulnerability gene is...
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