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Article

The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension.

American journal of hypertension - 1 Oct 2005

Dreisbach Albert W, Japa Shanker, Sigel Aster, Parenti Melissa B, Hess Arthur E, Srinouanprachanh Sengkeo L, Rettie Allan E, Kim Helen, Farin Federico M, Hamm L Lee, Lertora Juan J L

Abstract excerpt

BACKGROUND: The cytochrome P450 (CYP) epoxygenase pathway produces arachidonic acid metabolites that are vasoactive, that affect renal sodium handling, and that have been proposed to play a mechanistic role in hypertension. Multiple single nucleotide polymorphisms (SNP) in CYP2C8, 2C9, 2J2 and soluble epoxide hydrolase (sEH) have been identified, many of which have altered functional activity in vitro. We...

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Identifiers

PMID: 16202848
DOI: 10.1016/j.amjhyper.2005.04.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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