Article
The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2017
Polonikov Alexey, Bykanova Marina, Ponomarenko Irina, Sirotina Svetlana, Bocharova Anna, Vagaytseva Kseniya, Stepanov Vadim, Churnosov Mikhail, Bushueva Olga, Solodilova Maria, Shvetsov Yaroslav, Ivanov Vladimir
Abstract excerpt
Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway of arachidonic acids metabolism for the pathogenesis of essential hypertension (EH). The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) of CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), and CYP2C19 (rs4244285) are associated with susceptibility to...