Article
Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.
Annals of human genetics - 1 Jul 2007
Wu Sheng-Nan, Zhang Yi, Gardner Charles O, Chen Qi, Li Yan, Wang Gu-Liang, Gao Ping-Jin, Zhu Ding-Liang
Abstract excerpt
OBJECTIVE: Evidence from animal models and human studies suggests that CYP2J2 plays a mechanistic role in the development of hypertension. The present study aims to investigate the potential genetic contribution of the CYP2J2 gene to the etiology of essential hypertension (EH) and individual blood pressure. METHODS: We selected eight polymorphisms in/or around the CYP2J2 gene and performed a case-control...
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