Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Feb 2019

Polonikov Alexey V, Ponomarenko Irina V, Bykanova Marina A, Sirotina Svetlana S, Bocharova Anna V, Vagaytseva Kseniya V, Stepanov Vadim A, Azarova Iuliia E, Churnosov Mikhail I, Solodilova Maria A

Abstract excerpt

This study investigated whether common polymorphisms of cytochrome P450 2J2 (CYP2J2), a major enzyme that controls the biosynthesis of vasoactive epoxyeicosatrienoic acids, are collectively involved in the molecular basis of essential hypertension (EH). A total of 2314 unrelated Russian subjects from the Kursk (discovery sample: 913 EH patients and 645 controls) and Belgorod (replication sample: 345 EH patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, Metabolism, and Disease
Share to Eicosanoids and Hypertension Pharmacology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hormonal Regulation and Hypertension

Source

Identifiers

PMID: 30518987
DOI: 10.1038/s41440-018-0142-1

Genes

CYP2J2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive study revealed SNP–SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension riskPMID 30518987Read ↗

Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.Semantic proximity Read ↗

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?Semantic proximity Read ↗

Association of genetic polymorphisms of CYP 2C19 with hypertension in a Chinese Han population.Semantic proximity Read ↗

Gene-environment interactions of selected pharmacogenes in arterial hypertension.Semantic proximity Read ↗

Genetics of hypertension-related sex differences and hypertensive disorders of pregnancySemantic proximity Read ↗

Genetic determinants of hypertension: A meta-analysis of AGTR1 and CYP11B2 gene polymorphisms.Semantic proximity Read ↗

Genetic variations related to hypertension: a review.Semantic proximity Read ↗

Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.Semantic proximity Read ↗

A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population.Semantic proximity Read ↗

Hypertension and SNP genotyping in antihypertensive treatment.Semantic proximity Read ↗

Association between p22PHOX gene C242T polymorphism and hypertension in end-stage kidney disease patients.Semantic proximity Read ↗

A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.