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Article

Pharmacological characterization of tegaserod at the wild type and 124Cys variant of the human 5-HT1B receptor.

Pharmacogenetics and genomics - 1 Jul 2011

Haenisch Britta, Bönisch Heinz

Abstract excerpt

Sumatriptan, an antimigraine drug, causes contraction of human coronary arteries through activation of 5-HT1B receptors which couple to Gi/Go inducing inhibition of adenylate cyclase. At a rare, naturally occurring human receptor variant (124Cys-h5-HT1B), sumatriptan has previously been shown to act as a more potent agonist than at wild-type receptor. Tegaserod, a 5-HT4-receptor agonist, developed for the...

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PMID: 21478802
DOI: 10.1097/FPC.0b013e3283469f1d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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