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Article

Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT(2A) receptor.

Cellular signalling - 1 Apr 2013

Barclay Zoe, Dickson Louise, Robertson Derek, Johnson Melanie, Holland Pamela, Rosie Roberta, Sun Liting, Jerina Helen, Lutz Eve, Fleetwood-Walker Sue, Mitchell Rory

Abstract excerpt

The 5-HT2A receptor (5-HT2AR) is implicated in psychotropic changes within the central nervous system (CNS). A number of polymorphisms have been reported in the 5-HT2AR gene; one of these results in a non-synonymous change, H452Y, in the carboxy-terminal tail of the receptor protein. The minor al...

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Source

Identifiers

PMID: 23314176
DOI: 10.1016/j.cellsig.2013.01.004

Genes

PLD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23314176-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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