Mouse genetic background influences severity of immune responses following trauma-hemorrhage.

doi:10.1016/j.cyto.2004.12.019

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Article

Mouse genetic background influences severity of immune responses following trauma-hemorrhage.

Cytokine - 21 May 2005

Matsutani Takeshi, Anantha Samy T S, Kang Shih-Ching, Bland Kirby I, Chaudry Irshad H

Abstract excerpt

Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic background of the animal influence immune functions after trauma-hemorrhage. The aim of our studies,...

Topics

Animals
Bone Marrow Cells
Cell Proliferation
Genetic Predisposition to Disease
Hemorrhage
Immunity, Cellular
Interferon-gamma
Interleukin-10
Interleukin-2
Macrophages
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Spleen
Tumor Necrosis Factor-alpha
Wounds and Injuries

Source

Open in PubMed

Identifiers

PMID: 15863390
DOI: 10.1016/j.cyto.2004.12.019

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