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Host Genetic Variations and Sex Differences Potentiate Predisposition, Severity, and Outcomes of Group A Streptococcus-Mediated Necrotizing Soft Tissue Infections.

Infection and immunity - 1 Feb 2016

Chella Krishnan Karthickeyan, Mukundan Santhosh, Alagarsamy Jeyashree, Laturnus Donna, Kotb Malak

Abstract excerpt

Host genetic variations play an important role in several pathogenic diseases, and we previously provided strong evidence that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive group A Streptococcus (GAS) patients, including sepsis and necrotizing soft tissue infections (NSTIs). The goal of the present study was to investigate how genetic...

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Identifiers

PMID: 26573737
DOI: 10.1128/IAI.01191-15
PMCID: PMC4730561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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