Article
Susceptibility to severe Streptococcal sepsis: use of a large set of isogenic mouse lines to study genetic and environmental factors.
Genes and immunity - 1 Jul 2007
Aziz R K, Kansal R, Abdeltawab N F, Rowe S L, Su Y, Carrigan D, Nooh M M, Attia R R, Brannen C, Gardner L A, Lu L, Williams R W, Kotb M
Abstract excerpt
Variation in responses to pathogens is influenced by exposure history, environment and the host's genetic status. We recently demonstrated that human leukocyte antigen class II allelic differences are a major determinant of the severity of invasive group A streptococcal (GAS) sepsis in humans. While in-depth controlled molecular studies on populations of genetically well-characterized humans are not feasible, it...
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