Article
Genetic background determines susceptibility during murine septic peritonitis.
The Journal of surgical research - 1 Jan 2002
Godshall Christopher J, Scott Melanie J, Peyton James C, Gardner Sarah A, Cheadle William G
Abstract excerpt
BACKGROUND: The tolerance of mouse strains to cecal ligation and puncture (CLP), a clinically relevant model of sepsis, can vary greatly. We compared the immune response and bacterial eradication during CLP in two mouse strains with different susceptibilities to the lethal effects in an effort to understand alterations in tolerance. MATERIALS AND METHODS: CLP of increasing severity was performed on Swiss Webster...
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