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Article

COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population.

European journal of pain (London, England) - 1 Jun 2005

Armero Pilar, Muriel Clemente, Santos Juan, Sànchez-Montero F J, Rodríguez Raquel E, González-Sarmiento Rogelio

Abstract excerpt

It is well known that the response to painful stimuli varies between individuals and this could be consequence of individual differences to pain sensitivity that may be related to genetic factors. Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters. Differences in the activity of COMT influence the functions of these neurotransmitters. A single nucleotide...

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Source

Identifiers

PMID: 15862471
DOI: 10.1016/j.ejpain.2004.06.005

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population.PMID 15862471Read ↗

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COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor.Semantic proximity Read ↗

The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.Semantic proximity Read ↗

No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study.Semantic proximity Read ↗

No Association between Genetic Variants of the COMT and OPRM1 Genes and Pain Perception among Patients Undergoing Total Hip or Knee Arthroplasty for Primary Osteoarthritis.Semantic proximity Read ↗

COMT gene locus: new functional variants.Semantic proximity Read ↗

The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients?Semantic proximity Read ↗

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Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population.Semantic proximity Read ↗

Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population.Semantic proximity Read ↗

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