Article
Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.
Pharmacological reviews - 1 Jul 2014
Ahles Andrea, Engelhardt Stefan
Abstract excerpt
The human genome encodes nine different adrenoceptor genes. These are grouped into three families, namely, the α1-, α2-, and β-adrenoceptors, with three family members each. Adrenoceptors are expressed by most cell types of the human body and are primary targets of the catecholamines epinephrine and norepinephrine that are released from the sympathetic nervous system during its activation. Upon catecholamine...
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