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Article

Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements.

European journal of clinical pharmacology - 1 Mar 2010

Cadamuro Janne, Dieplinger Benjamin, Felder Thomas, Kedenko Igor, Mueller Thomas, Haltmayer Meinhard, Patsch Wolfgang, Oberkofler Hannes

Abstract excerpt

OBJECTIVE: The variability in warfarin dose requirement is attributable to genetic and environmental factors. Acenocoumarol (AC) and phenprocoumon (PC) are coumarin derivates widely prescribed in European countries for the prevention and treatment of thromboembolic events. The aim of our study wa...

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Source

Identifiers

PMID: 20020283
DOI: 10.1007/s00228-009-0768-7

Genes

VKORC1
APOE
CALU
GGCX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20020283-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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